Dear small protein enthusiasts, Over the past decade, modern genomics and transcriptomics have discovered a wealth of hidden small genes containing short open reading frames (sORFs) in many prokaryotic genomes. These sORFs encoding small proteins of <50 amino acids in length are typically missed by automated gene predictions. Recent efforts focusing on their functions have […]

“Type I toxin-dependent generation of superoxide affects the persister life cycle of Escherichia coli” Daniel Edelmann* & Bork A. Berghoff* *SPP 2002 member Abstract:Induction of growth stasis by bacterial toxins from chromosomal toxin-antitoxin systems is suspected to favor formation of multidrug-tolerant cells, named persisters. Recurrent infections are often attributed to resuscitation and regrowth of persisters […]